Benefits of time‐resolved nonuniform sampling in reaction monitoring: The case of aza‐Michael addition of benzylamine and acrylamide

Dariusz Gołowicz, Magdalena Kaźmierczak and Krzysztof Kazimierczuk*

Time‐resolved nonuniform sampling (TR‐NUS) applied to reaction monitoring eliminates 2D spectral line disturbances resulting from varying peak intensities and positions. This allows, in turn, avoiding wrong conclusions about kinetics. These considerations are exemplified with a seemingly simple aza‐Michael reaction of benzylamine and acrylamide. Surprisingly, the product identification is possible only using 2D spectra, although credible monitoring requires TR‐NUS.

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